construction of a plasmid containing d 297g mutation of v2 vasopressin receptor
نویسندگان
چکیده
منابع مشابه
Palmitoylation of the V2 vasopressin receptor.
Palmitoylation of the V2 vasopressin receptor (V2R) and its functional role were investigated in transfected cells. Palmitoylation was assessed by incubating transfected cells with [3H]palmitic acid and immunoprecipitating the receptor with an antibody raised against a portion of the third intracellular loop of V2R. Wild-type and nonglycosylated V2R yielded tritium signals at 45-55 and 40 kDa, ...
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بررسی نقش گفتمان در شکل گیری یا کاهش انگیزش فراگیران زبان خارجی موضوع تحقیق نسبتاً جدیدی است. از این رو، تحقیقات کمی در این زمینه وجود دارد. به منظور پر کردن این خلاء ، مطالعه کنونی به بررسی فرآیند گفتمان مدار شکل گیری یا کاهش انگیزش دانشجویان ایرانی زبان انگلیسی پرداخت. نخست، این مطالعه به صورت آزمایشی با 7 نفر (? دانشجوی پسر و 5 دختر) از دانشجویان سال دوم دوره ی کارشناسی زبان و ادبیات انگلیسی ...
Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene.
The V2 vasopressin receptor (V2R) plays a key role in the maintenance of a normal body water balance. To generate an in vivo model that allows the physiological and molecular analysis of the role of V2Rs in kidney function, we have created mouse lines that lack functional V2Rs by using targeted mutagenesis in mouse embryonic stem cells. Specifically, we introduced a nonsense mutation known to c...
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15 صفحه اولMutation of the histidin residue of the DRH motif in vasopressin V2 receptor expression and function
BACKGROUND AND THE PURPOSE OF THE STUDY Vasopressin type 2 receptor (V2R), a G protein coupled receptor (GPCR), plays an important role in the regulation of renal antidiuretic function. The highly conserved DRH motif is essential for G protein signaling of V2R; however its role especially regarding the histidin residue is not fully understood.. METHODS Site directed mutagenesis was performed ...
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Receptor recycling plays a critical role in the regulation of cellular responsiveness to environmental stimuli. Agonist-promoted phosphorylation of G protein-coupled receptors has been related to their desensitization, internalization, and sequestration. Dephosphorylation of internalized G protein-coupled receptors by cytoplasmic phosphatases has been shown to be pH-dependent, and it has been p...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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